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KMID : 1161520180220030178
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Animal Cells and Systems
2018 Volume.22 No. 3 p.178 ~ p.188
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Inhibition of cell growth by cellular differentiation into adipocyte-like cells in dexamethasone sensitive cancer cell lines
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Kim Hea-In
Moon Sun-Ha
Lee Won-Cheol
Lee Hyeon-Jeong
Shivakumar Sharath Belame
Lee Sung-Ho
Park Bong-Wook
Rho Gyu-Jin
Jeon Byeong-Gyun
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Abstract
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The stress responses in human body lead to secretion of cortisol hormone. The present study investigated the cellular responses on cell growth and cellular differentiation into adipocytes by exposure of synthetic stress hormone, dexamethasone (DEX) in various human cancer and normal cells. After prolonged exposure of cells with 1?μg/ml DEX for 2 weeks, population doubling time (PDT) was significantly (P?
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KEYWORD
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Human, cancer, dexamethasone, cell differentiation, adipocytes
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